Menene alaƙa tsakanin lafiyar ɗan adam da apigenin?

Nazarin dabbobi sun nuna cewa apigenin na iya hana maye gurbi da ke faruwa a cikin sel waɗanda ke da guba da ƙwayoyin cuta.[2][3] Hakanan Apigenin na iya taka rawa kai tsaye wajen kawar da radicals masu kyauta, hana haɓakar ƙwayoyin cuta, da shigar da enzymes na detoxification kamar glutathione.[4][5][6][7] Ƙwararrun ƙwayar cuta ta Apigenin na iya yin bayanin tasirinsa akan lafiyar hankali, aikin kwakwalwa, da amsawar rigakafi, [8] [7] [10] [9] ko da yake wasu manyan nazarin binciken ba su goyi bayan wannan ƙarshe ba game da yanayin rayuwa. [11]

Shaida ta farko ta nuna cewa apigenin na iya aiki azaman anti-oxidant, anti-mai kumburi, da / ko ma'ana don tsayayya da kamuwa da cuta. Sakamakon anti-mai kumburi na Apigenin (yawanci ana gani a 1-80 µM taro) na iya samuwa daga ikonsa na murkushe ayyukan wasu enzymes (NO-synthase da COX2) da cytokines (interleukins 4, 6, 8, 17A, TNF-α). ) waɗanda aka sani suna da hannu a cikin amsawar kumburi da rashin lafiyan. A gefe guda kuma, abubuwan da ake amfani da su na apigenin (100-279 µM / L) na iya kasancewa a wani ɓangare na ikonsa na ɓata radicals kyauta da kuma kare DNA daga lalacewa mai lalacewa. na parasites (5-25 μg / ml), microbial biofilms (1 mM), da ƙwayoyin cuta (5-50μM), yana nuna cewa yana iya samun damar inganta juriya ga kamuwa da cuta.

Ko da yake akwai ƙananan shaida na asibiti akan hulɗar apigenin tare da lafiyar lafiyar jiki, abin da yake a yanzu yana nuna wasu anti-inflammatory anti-oxidant, da kuma juriya na kamuwa da cuta ta hanyar inganta ayyukan enzyme antioxidant, alamun tsufa, atopic dermatitis, periodontitis na kullum, da kuma saukarwa. hadarin kamuwa da ciwon sukari nau'in II. Ya kamata a lura, duk da haka, cewa duk shaidun asibiti suna bincika apigenin a matsayin tushen tushensa (misali, tsire-tsire, ganye, da dai sauransu) ko kuma a matsayin wani abu mai mahimmanci, don haka ba za a iya danganta waɗannan tasirin ga apigenin kadai ba.

A cikin binciken bincike na farko (dabba da tantanin halitta), apigenin ya nuna tasiri akan damuwa, neuroexcitation, da neurodegeneration. An kuma lura da tasirin neuroprotective, wanda aka ba da shi ta hanyar haɓaka ƙarfin mitochondrial, a cikin nazarin dabba (1-33 μM).

Ƙananan karatun asibiti suna fassara waɗannan sakamakon zuwa cikin mutane. Biyu daga cikin mafi kyawun binciken sunyi nazarin apigenin a matsayin wani ɓangare na chamomile (Matricaria recutita) don damuwa da ƙaura. Lokacin da mahalarta tare da haɗin gwiwa na damuwa da damuwa an ba su 200-1,000 MG na cirewar chamomile a kowace rana don makonni 8 (ma'auni zuwa 1.2% apigenin), masu bincike sun lura da ingantawa a cikin ma'auni na kai-da-kai da damuwa. A cikin irin wannan gwaji na giciye, mahalarta tare da ƙaura sun sami raguwa a cikin ciwo, tashin zuciya, amai, da haske / amo hankali minti 30 bayan aikace-aikacen chamomile oleogel (0.233 mg / g na apigenin).

Apigenin kuma na iya yin tasiri mai kyau na physiologic martani ta hanyar rage cortisol, hormone damuwa. Lokacin da sel adrenocortical ɗan adam (a cikin vitro) aka fallasa su zuwa kewayon 12.5-100 μM flavonoid gaurayawan da suka haɗa da apigenin a matsayin sashi, samar da cortisol ya ragu har zuwa 47.3% idan aka kwatanta da sel masu sarrafawa.
A cikin berayen, apigenin da aka samo daga shuka Cephalotaxus sinensis na dangin Plum Yew ya nuna wasu kaddarorin anti-ciwon sukari ta hanyar haɓaka martanin physiologic ga insulin. Har yanzu ba a sake maimaita waɗannan sakamakon a cikin ɗan adam ba, kodayake a cikin binciken da ya ba mahalarta wani abin sha na barkono baƙar fata wanda ya ƙunshi apigenin da ƙalubalen burodin alkama, glucose jini da insulin ba su da bambanci da rukunin abubuwan sha.
Hormones na haihuwa kamar testosterone da estrogen na iya shafar apigenin. A cikin binciken da ya dace, apigenin ya canza masu karɓar enzyme da kuma aiki a hanyar da ke nuna cewa zai iya rinjayar aikin testosterone, har ma a ƙananan ƙananan (5-10 μM).
A 20 μM, ƙwayoyin ciwon nono da aka fallasa zuwa apigenin na tsawon sa'o'i 72 sun nuna hana haɓakawa ta hanyar sarrafa masu karɓar isrogen. Hakazalika, lokacin da kwayoyin ovarian suka fallasa zuwa apigenin (100 nM na 48 hours) masu bincike sun lura da hana ayyukan aromatase, wanda ake tunanin zai iya zama wata hanya ta hanyar rigakafi da maganin ciwon nono. Har yanzu ba a san yadda waɗannan tasirin za su fassara zuwa kashi na baki don amfanin ɗan adam ba.

Abubuwan da ke tattare da rayuwa da kwanciyar hankali na flavonoid apigenin a keɓe suna ƙoƙarin haifar da binciken ɗan adam tare da mai da hankali kan amfani ta hanyar shuke-shuke, ganyaye, da abubuwan da aka samu. Samuwar halittu da kuma sha na gaba, ko da daga tushen shuka da abinci, na iya bambanta kowane mutum da tushen da aka samo shi. Nazarin nazarin cin abincin flavonoid na abinci (ciki har da apigenin, wanda aka sanya shi a matsayin flavone) da kuma fitar da ruwa tare da haɗarin kamuwa da cuta, na iya zama mafi kyawun hanyoyin tantancewa. Ɗaya daga cikin manyan binciken da aka lura, alal misali, ya gano cewa daga cikin dukkanin nau'o'in flavonoid na abinci, cin abinci na apigenin kadai ya ɗauki 5% rage hadarin hawan jini ga mahalarta waɗanda suka cinye mafi yawan adadin, idan aka kwatanta da mahalarta suna cinye mafi ƙasƙanci. Yana yiwuwa ko da yake, akwai wasu bambance-bambancen da zasu iya bayyana wannan ƙungiya, irin su samun kudin shiga, wanda zai iya rinjayar yanayin kiwon lafiya da samun damar kulawa, yana haifar da raguwar haɗarin hauhawar jini. Gwajin bazuwar daya sami wani tasiri tsakanin amfani da abinci mai wadatar apigenin (albasa da faski) akan alamomin halittu masu alaƙa da hauhawar jini (misali, tara platelets da abubuwan da suka gabace wannan tsari). Abin lura anan shine ba za'a iya auna plasma apigenin a cikin jinin mahalarta ba, don haka tsawon lokaci da bambance-bambancen amfani ko watakila ma hanyoyi daban-daban, irin su matakan sakamako waɗanda ba su mayar da hankali kawai kan haɗawar platelet ba, ana iya buƙata don fahimta. m effects.

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[2]. Tajdar Husain Khan, Tamanna Jahangir, Lakshmi Prasad, Sarwat Sultana Inhibitory sakamako na apigenin a kan benzo(a) pyrene-tsatsakaicin genotoxicity a Swiss albino miceJ Pharm Pharmacol.(2006 Dec)
[3]. Kuo ML, Lee KC, Lin JKGenotoxicities na nitropyrenes da daidaitawar su ta apigenin, tannic acid, ellagic acid da indole-3-carbinol a cikin tsarin Salmonella da CHO.Mutat Res.(1992-Nuwamba-16)
[4]. Myhrstad MC, Carlsen H, Nordström O, Blomhoff R, Moskaug JØFlavonoids suna haɓaka matakin glutathione na ciki ta hanyar kunna gamma-glutamylcysteine ​​​​synthetase catalytical subunit promoter.Free Radic Biol Med.(2002-Mar-01)
[5]. Middleton E, Kandaswami C, Theoharides TCTallafin shuka flavonoids akan ƙwayoyin mammalian: abubuwan da ke haifar da kumburi, cututtukan zuciya, da ciwon daji.Pharmacol Rev.(2000-Dec)
[6]. H Wei, L Tye, E Bresnick, DF Birt Tasirin hanawa na apigenin, flavonoid shuka, akan epidermal ornithine decarboxylase da haɓakar ƙwayar ƙwayar cuta a cikin miceCancer Res.(1990 Feb 1)
[7].Gaur K, Siddique YHE Sakamakon apigenin akan cututtuka na neurodegenerative.CNS Neurol Disord Drug Targets.(2023-Apr-06)
[8].Sun Y, Zhao R, Liu R, Li T, Ni S, Wu H, Cao Y, Qu Y, Yang T, Zhang C, Sun YI Haɗe da Nuna Ƙaƙƙarfan Ƙarƙashin Ƙarƙashin Ƙarfafawa na Zhi-Zi-Hou- Po Decoction via da Network Pharmacology Analysis na Ƙarshen Pharmacodynamic Material da Mechanism.ACS Omega.(2021-Apr-06)
[9]Arsić I, Tadić V, Vlaović D, Homšek I, Vesić S, Isailović G, Vuleta GPreparation na novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations a matsayin madadin corticosteroid therapy.Phytother Res. - Fabrairu)
[10]. Dourado NS, Souza CDS, de Almeida MMA, Bispo da Silva A, Dos Santos BL, Silva VDA, De Assis AM, da Silva JS, Souza DO, Costa MFD, Butt AM, Costa SLNeuroimmunomodulatory da Neuroprotective Effects na Flavonoid Apigenin a cikin Models na Neuroinflammation hade da cutar Alzheimer.Front Aging Neurosci.(2020)
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