He aha ka pilina ma waena o ke olakino kanaka a me ka apigenin?

Hōʻike nā haʻawina holoholona e hiki i ka apigenin ke keʻakeʻa i ka hoʻololi ʻana o ka genetic i loko o nā cell i ʻike ʻia i nā toxins a me nā maʻi bacteria.[2][3] Hiki i ka Apigenin ke pāʻani pololei i ka wehe ʻana i nā radical manuahi, ka pale ʻana i nā enzymes ulu ulu, a me ka induction o nā enzyme detoxification e like me ka glutathione.[4][5][6][7] Hiki ke ho'ākāka 'ia ka mana anti-inflammatory o Apigenin i kona hopena ma ke olakino noʻonoʻo, ka hana o ka lolo, a me ka pane immunological, [8][7][10][9] ʻoiai ʻaʻole kākoʻo kekahi mau haʻawina nānā nui i kēia hopena e pili ana i nā kūlana metabolic. [11]

Hōʻike nā hōʻike preclinical e hiki ke lawelawe ʻo apigenin ma ke ʻano he anti-oxidant, anti-inflammatory, a / a i ʻole e pale aku i ka maʻi pathogenic. Hiki ke loaʻa nā hopena anti-inflammatory o Apigenin (ʻike pinepine ʻia ma 1-80 µM) mai kona hiki ke kāohi i ka hana o kekahi mau enzymes (NO-synthase a me COX2) a me nā cytokines (interleukins 4, 6, 8, 17A, TNF-α. ) i ʻike ʻia e pili ana i nā pane ʻeha a me nā maʻi maʻi. Ma ka ʻaoʻao ʻē aʻe, ʻo nā waiwai anti-oxidant o apigenin (100-279 µM/L) ma muli paha o kona hiki ke ʻoki i nā radical manuahi a pale i ka DNA mai ka pōʻino radical manuahi. o nā parasites (5-25 μg/ml), microbial biofilms (1 mM), a me nā maʻi (5-50μM), e manaʻo ana he hiki ke hoʻomaikaʻi i ke kū'ē i ka maʻi.

ʻOiai he liʻiliʻi nā hōʻike lapaʻau i loaʻa i ka pili ʻana o apigenin me ke olakino olakino, ʻo ka mea i kēia manawa ke hōʻike nei i kekahi anti-inflammatory anti-oxidant, a me nā pōmaikaʻi kūʻē i ka maʻi ma o ka hoʻomaikaʻi ʻana i ka hana antioxidant enzyme, nā hōʻailona o ka ʻelemakule, atopic dermatitis, periodontitis maʻi, a hoʻohaʻahaʻa ʻia. pilikia no ka maʻi diabetes type II. Pono e hoʻomaopopo ʻia, ʻo nā hōʻike lapaʻau āpau e ʻimi ana i ka apigenin ma ke ʻano he kumu o kona kumu (e laʻa, nā mea kanu, nā mea kanu, a me nā mea ʻē aʻe) a i ʻole he mea hoʻohui, no laila ʻaʻole hiki ke hoʻopili ʻia kēia mau hopena i ka apigenin wale nō.

Ma ka noiʻi preclinical (holoholona a me ka cell), ua hōʻike ʻo apigenin i nā hopena i ka hopohopo, neuroexcitation, a me ka neurodegeneration. ʻO nā hopena neuroprotective, i hāʻawi ʻia ma o ka hoʻonui ʻana i ka mana mitochondrial, ua ʻike pū ʻia i nā haʻawina holoholona (1-33 μM).

He liʻiliʻi nā haʻawina lapaʻau e unuhi i kēia mau hopena i ke kanaka. ʻElua o nā haʻawina hoʻohiki maikaʻi loa i nānā i ka apigenin ma ke ʻano he chamomile (Matricaria recutita) no ka hopohopo a me ka migraine. I ka manawa i hāʻawi ʻia ai nā poʻe me nā co-diagnoses o ka hopohopo a me ke kaumaha i ka 200-1,000 mg o ka chamomile extract i kēlā me kēia lā no 8 mau pule (maʻamau i ka 1.2% apigenin), ua ʻike nā mea noiʻi i ka hoʻomaikaʻi ʻana i ka hopohopo a me nā unahi kaumaha. I loko o kahi hoʻokolohua like ʻole, ua ʻike nā poʻe me ka migraine i ka emi ʻana o ka ʻeha, nausea, luaʻi, a me ka ʻike kukui / walaʻau 30 mau minuke ma hope o ka hoʻohana ʻana i kahi chamomile oleogel (0.233 mg / g o apigenin).

Hiki paha iā Apigenin ke hana i nā pane physiologic maikaʻi ma ka hoʻemi ʻana i ka cortisol, ka hormone stress. I ka wā i hōʻikeʻia ai nā pūnaewele adrenocortical kanaka (in vitro) i ka laulā o 12.5-100 μM flavonoids hui pū me ka apigenin ma ke ʻano he ʻāpana, ua emi iho ka hana cortisol a hiki i ka 47.3% ke hoʻohālikelike ʻia me nā cell control.
I nā ʻiole, ua hōʻike ʻia ka apigenin mai ka mea kanu Cephalotaxus sinensis o ka ʻohana Plum Yew i kekahi mau waiwai anti-diabetic ma o ka hoʻonui ʻana i ka pane physiologic i ka insulin. ʻAʻole i hana hou ʻia kēia mau hopena i loko o ke kanaka, akā naʻe i loko o kahi noiʻi i hāʻawi i nā poʻe i kahi inu pepa ʻeleʻele i loaʻa ka apigenin a me ka ʻai palaoa hoʻokūkū, ʻaʻohe ʻokoʻa o ka glucose koko a me ka insulin mai ka hui hoʻomalu.
Hiki ke hoʻopili ʻia nā hormones reproductive e like me ka testosterone a me ka estrogen e ka apigenin. Ma nā haʻawina preclinical, ua hoʻololi ʻo apigenin i nā mea hoʻokipa enzyme a me ka hana ma ke ʻano e hōʻike ana hiki ke hoʻopilikia i ka hana testosterone, ʻoiai ma kahi haʻahaʻa haʻahaʻa (5-10 μM).
Ma 20 μM, ua hōʻike ʻia nā maʻi maʻi maʻi umauma i apigenin no nā hola 72 i hoʻopaʻa ʻia i ka hoʻonui ʻana ma o ka mālama ʻana i nā mea hoʻokipa estrogen. Pēlā nō, i ka wā i hōʻike ʻia ai nā ovarian cell i apigenin (100 nM no 48 mau hola) ua ʻike nā mea noiʻi i ka pale ʻana i ka hana aromatase, i manaʻo ʻia he hana hiki ke pale a mālama i ka maʻi kanesa o ka umauma. ʻAʻole maopopo naʻe, pehea e unuhi ʻia ai kēia mau hopena i loko o ka waha waha no ka ʻai kanaka.

ʻO nā pilikia bioavailability a me ke kūpaʻa o ka flavonoids apigenin i kahi kaʻawale ka hopena i ka noiʻi kanaka me ka nānā ʻana i ka ʻai ʻana ma o nā mea kanu, nā mea kanu, a me kā lākou mau mea. Hiki ke ʻano like ʻole ka bioavailability a me ka hoʻopili ʻana ma hope, mai nā kumu meaʻai a me nā kumu meaʻai, i kēlā me kēia kanaka a me ke kumu i loaʻa mai ai. ʻO nā haʻawina e nānā ana i ka ʻai ʻana i ka flavonoid meaʻai (me ka apigenin, ka mea i hoʻokaʻawale ʻia ma ke ʻano he flavone) a me ka excretion me ka pilikia o ka maʻi, no laila ʻo ia ke ala kūpono loa o ka loiloi. ʻO kahi haʻawina nānā nui, no ka laʻana, ʻike ʻia ʻo nā subclasses flavonoid meaʻai āpau, ʻo ka lawe ʻana i ka apigenin wale nō i lawe i ka 5% hoʻemi i ka pilikia no ka hypertension no nā poʻe i ʻai i ka nui kiʻekiʻe, ke hoʻohālikelike ʻia me nā poʻe e ʻai ana i ka mea haʻahaʻa. Hiki nō naʻe, aia kekahi mau ʻokoʻa ʻē aʻe e wehewehe i kēia hui, e like me ka loaʻa kālā, hiki ke hoʻopilikia i ke kūlana olakino a me ke komo ʻana i ka mālama, e alakaʻi ana i ka hōʻemi ʻana i ka maʻi hypertension. ʻAʻole ʻike ʻia kekahi hopena ma waena o ka ʻai ʻana i nā meaʻai momona apigenin (ka onion a me ka pā paʻi) i nā biomarkers e pili ana i ka hypertension (e laʻa, ka hui ʻana o nā platelets a me nā mea mua o kēia kaʻina hana). ʻO ka hōʻailona ma ʻaneʻi ʻaʻole hiki ke ana ʻia ka plasma apigenin i loko o ke koko o ka poʻe komo, no laila e pono ai ka hoʻohana ʻana i ka wā lōʻihi a i ʻole nā ​​ala like ʻole, e like me nā ana hopena ʻaʻole i kālele wale i ka platelet aggregation. nā hopena kūpono.

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