Dab tsi yog kev sib raug zoo ntawm tib neeg kev noj qab haus huv thiab apigenin?

Tsiaj cov kev tshawb fawb qhia tias apigenin tuaj yeem cuam tshuam kev hloov caj ces tshwm sim hauv cov hlwb uas raug rau co toxins thiab kab mob.[2][3] Apigenin kuj tseem tuaj yeem ua lub luag haujlwm ncaj qha hauv kev tshem tawm cov dawb radicals, inhibition ntawm qog loj hlob enzymes, thiab induction ntawm detoxification enzymes xws li glutathione.[4][5][6][7] Apigenin lub peev xwm los tiv thaiv kab mob kuj tseem tuaj yeem piav qhia txog nws cov txiaj ntsig ntawm kev puas siab puas ntsws, lub hlwb ua haujlwm, thiab cov lus teb tiv thaiv kab mob, [8][7][10][9] txawm tias qee qhov kev tshawb fawb loj tsis txhawb qhov kev txiav txim siab txog kev mob metabolic. [11]

Cov pov thawj preclinical qhia tias apigenin tuaj yeem ua cov tshuaj tiv thaiv oxidant, tiv thaiv kev mob, thiab / lossis txhais tau tias tiv thaiv kab mob. Apigenin's anti-inflammatory teebmeem (feem ntau pom ntawm 1-80 µM concentrations) tuaj yeem muab tau los ntawm nws lub peev xwm los txo qis kev ua haujlwm ntawm qee cov enzymes (NO-synthase thiab COX2) thiab cytokines (interleukins 4, 6, 8, 17A, TNF-α. ) uas paub tias muaj kev koom tes hauv inflammatory thiab allergic teb. Ntawm qhov tod tes, apigenin's anti-oxidant zog (100-279 µM / L) tej zaum yuav yog vim muaj ib feem ntawm nws lub peev xwm los tshem tawm cov dawb radicals thiab tiv thaiv DNA los ntawm kev puas tsuaj dawb radical. ntawm cov kab mob parasites (5-25 μg / ml), microbial biofilms (1 mM), thiab cov kab mob (5-50μM), qhia tias nws yuav muaj peev xwm txhim kho kev tiv thaiv kab mob.

Txawm hais tias muaj cov pov thawj me me muaj nyob rau ntawm apigenin kev cuam tshuam nrog kev tiv thaiv kab mob, qhov tam sim no qhia qee qhov kev tiv thaiv kev tiv thaiv oxidant, thiab kev tiv thaiv kab mob los ntawm kev txhim kho hauv kev ua haujlwm antioxidant enzyme, cov cim ntawm kev laus, atopic dermatitis, mob periodontitis, thiab txo qis. kev pheej hmoo rau ntshav qab zib hom II. Nws yuav tsum raug sau tseg, txawm li cas los xij, tag nrho cov pov thawj kho mob tshawb nrhiav apigenin raws li cov khoom siv ntawm nws qhov chaw (piv txwv li, nroj tsuag, tshuaj ntsuab, thiab lwm yam) lossis ua cov khoom xyaw ntxiv, yog li cov teebmeem no tsis tuaj yeem raug ntaus nqi rau apigenin ib leeg.

Hauv kev tshawb fawb preclinical (tsiaj thiab cell), apigenin tau nthuav tawm cov teebmeem ntawm kev ntxhov siab, neuroexcitation, thiab neurodegeneration.Nyob rau hauv kev tshawb nrhiav nas, ntau npaum li cas ntawm 3-10 mg / kg ntawm lub cev qhov hnyav ua rau txo qis hauv kev ntxhov siab yam tsis ua rau sedation.[2] Cov teebmeem neuroprotective, tau hais los ntawm kev muaj peev xwm mitochondrial, kuj tau pom nyob rau hauv kev tshawb fawb tsiaj (1-33 μM).

Qee qhov kev tshawb fawb soj ntsuam txhais cov txiaj ntsig no rau tib neeg. Ob qhov kev tshawb fawb tau zoo tshaj plaws tau tshuaj xyuas apigenin raws li ib feem ntawm chamomile (Matricaria recutita) rau kev ntxhov siab thiab mob migraine. Thaum cov neeg koom nrog kev kuaj mob ntawm kev ntxhov siab thiab kev nyuaj siab tau muab 200-1,000 mg ntawm chamomile extract ib hnub rau 8 lub lis piam (tus qauv rau 1.2% apigenin), cov kws tshawb fawb pom kev txhim kho ntawm tus kheej qhia txog kev ntxhov siab thiab kev nyuaj siab. Hauv kev sim sib tw zoo sib xws, cov neeg koom nrog migraine tau ntsib kev txo qis hauv qhov mob, xeev siab, ntuav, thiab lub teeb / suab nrov 30 feeb tom qab siv chamomile oleogel (0.233 mg / g ntawm apigenin).

Apigenin kuj tseem tuaj yeem ua rau lub cev muaj txiaj ntsig zoo los ntawm kev txo cov cortisol, cov tshuaj hormones ntxhov siab. Thaum tib neeg cov hlwb adrenocortical (hauv vitro) tau raug rau ntau yam ntawm 12.5-100 μM flavonoid sib xyaw uas suav nrog apigenin ua ib feem, cortisol ntau lawm tau txo mus txog 47.3% piv rau cov tswj hlwb.
Hauv cov nas, apigenin muab rho tawm los ntawm cov nroj tsuag Cephalotaxus sinensis ntawm Plum Yew tsev neeg tau pom qee qhov kev tiv thaiv kab mob ntshav qab zib los ntawm kev ua kom lub cev teb rau insulin. Cov txiaj ntsig no tseem tsis tau rov ua dua rau tib neeg, txawm hais tias hauv txoj kev tshawb fawb uas tau muab cov neeg koom nrog haus kua txob dub uas muaj apigenin thiab cov nplej nplej zom mov, cov ntshav qabzib thiab insulin tsis txawv ntawm pawg tswj dej haus.
Kev tsim cov tshuaj hormones xws li testosterone thiab estrogen kuj tseem cuam tshuam los ntawm apigenin. Hauv kev tshawb fawb preclinical, apigenin hloov kho enzyme receptors thiab kev ua haujlwm hauv ib txoj hauv kev uas qhia tias nws tuaj yeem cuam tshuam rau kev ua haujlwm ntawm testosterone, txawm tias tsawg (5-10 μM) ntau npaum li cas.
Ntawm 20 μM, cov qog nqaij hlav cancer mis raug rau apigenin rau 72 teev pom tias inhibited proliferation los ntawm kev tswj cov tshuaj estrogen receptors. Ib yam li ntawd, thaum lub zes qe menyuam raug rau apigenin (100 nM rau 48 teev) cov kws tshawb fawb tau pom tias muaj kev cuam tshuam ntawm aromatase kev ua haujlwm, uas yog xav tias yog ib qho kev ua tau zoo hauv kev tiv thaiv thiab kho mob qog noj ntshav. Nws tseem tsis paub meej, txawm li cas los xij, cov teebmeem no yuav txhais li cas rau hauv qhov ncauj koob tshuaj rau tib neeg noj.

Cov teeb meem bioavailability thiab stability ntawm flavonoid apigenin nyob rau hauv kev sib cais yuav ua rau tib neeg kev tshawb fawb nrog rau kev tsom mus rau kev noj los ntawm cov nroj tsuag, tshuaj ntsuab, thiab lawv cov extracts. Bioavailability thiab kev nqus tom qab, txawm tias los ntawm cov nroj tsuag thiab zaub mov, kuj yuav txawv ntawm ib tus neeg thiab qhov chaw nws tau muab los ntawm. Cov kev tshawb fawb soj ntsuam kev noj haus flavonoid kom tsawg (xws li apigenin, uas yog sub-classed as a flavone) thiab excretion nrog rau kev pheej hmoo rau tus kab mob, yog li ntawd yuav yog qhov siv tau zoo tshaj plaws ntawm kev soj ntsuam. Ib qho kev soj ntsuam loj, piv txwv li, pom tias ntawm tag nrho cov kev noj haus flavonoid subclasses, kev noj cov tshuaj apigenin ib leeg ua rau 5% txo qhov kev pheej hmoo rau ntshav siab rau cov neeg koom nrog uas tau noj ntau tshaj plaws, piv rau cov neeg koom siv qis tshaj. Txawm li cas los xij, nws muaj peev xwm hais tias muaj lwm qhov sib txawv uas yuav piav qhia txog lub koom haum no, xws li cov nyiaj tau los, uas tuaj yeem cuam tshuam txog kev noj qab haus huv thiab kev nkag mus rau kev saib xyuas, ua rau txo qis kev pheej hmoo siab. Ib qho kev sim randomized pom tsis muaj kev cuam tshuam ntawm kev noj cov zaub mov nplua nuj ntawm apigenin (dos thiab parsley) ntawm biomarkers ntsig txog kev kub siab (xws li, kev sib sau ntawm platelets thiab precursors ntawm cov txheej txheem no). Lub caveat ntawm no yog tias plasma apigenin tsis tuaj yeem ntsuas hauv cov neeg koom nrog cov ntshav, yog li lub sij hawm ntev thiab kev siv ntau yam los yog tej zaum txawm tias muaj ntau txoj hauv kev, xws li cov txiaj ntsig ntsuas uas tsis yog tsom rau platelet aggregation, tej zaum yuav xav tau kom nkag siab. tej yam tshwm sim.

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