Kedu njikọ dị n'etiti ahụike mmadụ na apigenin?

Ọmụmụ anụmanụ na-egosi na apigenin nwere ike igbochi mmụgharị mkpụrụ ndụ ihe nketa na-eme na sel ndị na-ekpughere nsị na nje bacteria.[2][3] Apigenin nwekwara ike na-arụ ọrụ kpọmkwem na mwepụ nke free radicals, mgbochi nke tumor growth enzymes, na ntinye nke detoxification enzymes dị ka glutathione.[4][5][6][7] Ike mgbochi mkpali nke Apigenin nwekwara ike ịkọwa mmetụta ya na ahụike uche, ọrụ ụbụrụ, na nzaghachi immunological, [8] [7] [10] [9] ọ bụ ezie na ụfọdụ nnukwu nnyocha nyocha anaghị akwado nkwubi okwu a gbasara ọnọdụ metabolic. [11]

Ihe akaebe izizi na-egosi na apigenin nwere ike ịbụ ihe na-egbochi oxidant, mgbochi mkpali, na/ma ọ bụ ụzọ iji guzogide ọrịa nje. Enwere ike nweta mmetụta mgbochi mkpali nke Apigenin (nke a na-ahụkarị na 1-80 µM mkpokọta) site na ikike ya igbochi ọrụ ụfọdụ enzymes (NO-synthase na COX2) na cytokines (interleukins 4, 6, 8, 17A, TNF-α). ) nke a maara na ọ na-etinye aka na mmeghachi omume mkpali na nke nfụkasị ahụ. N'aka nke ọzọ, apigenin's anti-oxidant properties (100-279 µM/L) nwere ike ịbụ n'ihi na ọ nwere ike ịmegharị ihe ndị na-akpata free radicals ma chebe DNA pụọ na mmebi nke free radical. nke nje (5-25 μg / ml), microbial biofilms (1 mM), na nje (5-50μM), na-atụ aro na ọ nwere ike ime ka ọ dịkwuo mma iguzogide ọrịa.

Ọ bụ ezie na enwere ntakịrị ihe akaebe dị na mmekọrịta apigenin na ahụike ahụike, ihe dị ugbu a na-atụ aro ụfọdụ mgbochi mgbochi mkpali anti-oxidant, yana nguzogide ọrịa na-erite uru site na nkwalite ọrụ enzyme antioxidant, ihe ịrịba ama nke ịka nká, atopic dermatitis, periodontitis na-adịghị ala ala, na wedata. ihe ize ndụ maka ụdị ọrịa shuga II. Okwesiri iburu n'uche, na ihe akaebe nile nke ulo ogwu na-enyocha apigenin dika ihe mejupụtara ya (dika osisi, ogwu, wdg) ma obu dika ihe agbakwunyere, ya mere enweghi ike ikwu ihe ndi a na apigenin.

N'ime ọmụmụ ihe ọmụmụ (anụmanụ na sel), apigenin egosipụtala mmetụta na nchekasị, neuroexcitation, na neurodegeneration. Na nyocha nke òké, doses nke 3-10 mg / kg nke ịdị arọ ahụ na-emepụta mbelata na nchekasị n'emeghị ka ọ daa mbà [2]. Mmetụta Neuroprotective, nke enyere site na ụbara ikike mitochondrial, ka ahụkwara na ọmụmụ anụmanụ (1-33 μM).

Ọmụmụ ụlọ ọgwụ ole na ole na-asụgharị nsonaazụ ndị a n'ime mmadụ. Abụọ n'ime ihe ọmụmụ kachasị mma na-enyocha apigenin dị ka ihe mejupụtara chamomile (Matricaria recutita) maka nchekasị na migraine. Mgbe a na-enye ndị na-eso ụzọ nyocha nke nchegbu na ịda mbà n'obi 200-1,000 mg nke chamomile wepụ kwa ụbọchị maka izu 8 (nke a kwadoro na 1.2% apigenin), ndị nchọpụta hụrụ ọganihu na nchegbu onwe onye na ịda mbà n'obi. N'okwu ikpe a na-agafe agafe yiri nke ahụ, ndị sonyere na migraine nwere mbelata mgbu, ọgbụgbọ, ọgbụgbọ, na mmetụta ìhè / mkpọtụ nkeji 30 mgbe itinyechara chamomile oleogel (0.233 mg / g nke apigenin).

Apigenin nwekwara ike ị nweta nzaghachi physiologic dị mma site na ibelata cortisol, hormone nchekasị. Mgbe ekpughere mkpụrụ ndụ adrenocortical mmadụ (in vitro) n'ọtụtụ 12.5-100 μM flavonoid ngwakọta nke gụnyere apigenin dị ka akụkụ, mmepụta cortisol belatara ruo 47.3% ma e jiri ya tụnyere sel njikwa.
N'ime ụmụ oke, apigenin ewepụtara na osisi Cephalotaxus sinensis nke ezinụlọ Plum Yew gosipụtara ụfọdụ ihe na-egbochi ọrịa shuga site n'ịbawanye nzaghachi physiologic na insulin. E nweghachibeghị nsonaazụ ndị a na ụmụ mmadụ, ọ bụ ezie na n'ime nnyocha nke nyere ndị na-eso ya ihe ọṅụṅụ ose oji nke nwere apigenin na nri ọka ọka wit, glucose ọbara na insulin adịghị iche na ndị na-ahụ maka ihe ọṅụṅụ.
Apigenin nwekwara ike imetụta homonụ ịmụ nwa dị ka testosterone na estrogen. N'ime ọmụmụ ihe ọmụmụ, apigenin gbanwetụrụ ndị na-anabata enzyme na ọrụ n'ụzọ na-egosi na ọ nwere ike imetụta ọrụ testosterone, ọbụlagodi na obere (5-10 μM).
Na 20 μM, mkpụrụ ndụ cancer ara nke ekpughere na apigenin maka awa 72 gosipụtara na-egbochi mgbasa site na njikwa nke ndị na-anabata estrogen. N'otu aka ahụ, mgbe a na-ekpughere mkpụrụ ndụ ovarian na apigenin (100 nM maka awa 48) ndị nchọpụta hụrụ ihe mgbochi nke ọrụ aromatase, nke a na-eche na ọ bụ usoro nwere ike ime na mgbochi na ọgwụgwọ ọrịa cancer ara. Otú ọ dị, amabeghị ka mmetụta ndị a ga-esi tụgharịa gaa n'ọnụ ọnụ maka oriri mmadụ.

Ihe gbasara bioavailability na nkwụsi ike nke flavonoid apigenin dịpụrụ adịpụ na-ebute nyocha nke mmadụ na-elekwasị anya na oriri site na osisi, ahịhịa, na ihe ndị ha nwetara. Nnweta bioavailability na nnabata na-esote, ọbụlagodi site na ihe ọkụkụ na nri nri, nwekwara ike ịdịgasị iche n'otu n'otu yana ebe esitere na ya. Nnyocha na-enyocha oriri flavonoid nri (gụnyere apigenin, nke a na-ekewa dị ka flavone) na nsị n'akụkụ ihe ize ndụ nke ọrịa, nwere ike ịbụ ụzọ kachasị mma iji nyochaa. Otu nnukwu nnyocha nyocha, dịka ọmụmaatụ, chọpụtara na n'ime klas flavonoid niile na-eri nri, oriri nke apigenin naanị na-ebute mbelata 5% n'ihe ize ndụ maka ọbara mgbali elu maka ndị sonyere na-eri nri kachasị elu, ma e jiri ya tụnyere ndị na-eri nri kacha ala. Ọ ga-ekwe omume n'agbanyeghị, na enwere ọdịiche ndị ọzọ nwere ike ịkọwa mkpakọrịta a, dị ka ego, nke nwere ike imetụta ọnọdụ ahụike na ịnweta nlekọta, na-eduga ná mbelata ọbara mgbali elu. Otu nnwale enweghị usoro ahụghị mmetụta ọ bụla n'etiti oriri apigenin bara ụba (yabasị na pasili) na ihe ndị metụtara ọbara mgbali elu (dịka ọmụmaatụ, nchịkọta platelet na ihe ga-ebute usoro a). Ihe ịdọ aka ná ntị ebe a bụ na a pụghị ịtụ plasma apigenin n'ọbara ndị sonyere ya, yabụ ogologo oge na oriri dị iche iche ma ọ bụ ikekwe ụzọ dị iche iche, dị ka usoro nsonaazụ na-adịghị elekwasị anya naanị na nchịkọta platelet, nwere ike ịdị mkpa iji ghọta. mmetụta ndị nwere ike ime.

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