Kodi pali ubale wotani pakati pa thanzi la munthu ndi apigenin?

Kafukufuku wa zinyama akusonyeza kuti apigenin akhoza kulepheretsa kusintha kwa majini komwe kumachitika m'maselo omwe ali ndi poizoni ndi mabakiteriya.[2][3] Apigenin athanso kutenga nawo mbali pachindunji pochotsa ma free radicals, kuletsa ma enzymes okulitsa chotupa, komanso kulowetsa ma enzymes ochotsa poizoni monga glutathione.[4][5][6][7] Mphamvu ya Apigenin yolimbana ndi kutupa imatha kufotokozeranso zotsatira zake paumoyo wamaganizidwe, kugwira ntchito kwaubongo, komanso kuyankha kwa chitetezo chamthupi, [8] [7] [10] [9] ngakhale kafukufuku wina wamkulu sakugwirizana ndi izi pokhudzana ndi kagayidwe kachakudya. [11]

Umboni wa preclinical umasonyeza kuti apigenin ikhoza kukhala ngati anti-oxidant, anti-inflammatory, ndi/kapena njira yopewera matenda opatsirana. Zotsatira za anti-kutupa za Apigenin (zomwe zimawonedwa pa 1-80 μM zokhazikika) zitha kutengedwa kuchokera pakutha kuletsa ntchito ya ma enzymes (NO-synthase ndi COX2) ndi ma cytokines (interleukins 4, 6, 8, 17A, TNF-α). ) zomwe zimadziwika kuti zimakhudzidwa ndi zotupa komanso zosagwirizana nazo. Kumbali ina, anti-oxidant ya apigenin (100-279 µM/L) ikhoza kukhala chifukwa cha kuthekera kwake kuwononga ma free radicals ndikuteteza DNA ku kuwonongeka kwa ma free radicals. Tizilombo toyambitsa matenda (5-25 μg/ml), tizilombo tating'onoting'ono (1 mM), ndi ma virus (5-50μM), zomwe zikuwonetsa kuti zitha kukhala ndi mwayi wowongolera kukana matenda.

Ngakhale pali umboni wochepa wachipatala wokhudzana ndi kuyanjana kwa apigenin ndi thanzi la chitetezo cha mthupi, zomwe zilipo zikusonyeza kuti pali anti-inflammatory anti-oxidant, komanso ubwino wotsutsa matenda chifukwa cha kusintha kwa ntchito ya antioxidant enzyme, zizindikiro za ukalamba, atopic dermatitis, periodontitis, ndi kuchepa. chiopsezo cha matenda amtundu wa II. Komabe, ziyenera kuzindikirika kuti umboni wonse wachipatala umafufuza apigenin monga gawo la gwero lake (mwachitsanzo, zomera, zitsamba, ndi zina zotero) kapena monga chowonjezera, kotero zotsatirazi sizingakhale chifukwa cha apigenin yokha.

M'maphunziro a preclinical (anyama ndi ma cell), apigenin yawonetsa zotsatirapo pa nkhawa, chisangalalo, ndi neurodegeneration. Zotsatira za neuroprotective, zoperekedwa chifukwa cha kuchuluka kwa mitochondrial mphamvu, zawonedwanso mu maphunziro a nyama (1-33 μM).

Maphunziro ochepa azachipatala amamasulira zotsatirazi kukhala anthu. Maphunziro awiri odalirika kwambiri adafufuza apigenin monga gawo la chamomile (Matricaria recutita) chifukwa cha nkhawa ndi migraine. Pamene otenga nawo mbali omwe ali ndi chidziwitso cha nkhawa ndi kuvutika maganizo anapatsidwa 200-1,000 mg ya chamomile patsiku kwa masabata a 8 (omwe amadziwika kuti 1.2% apigenin), ochita kafukufuku adawona kusintha kwazomwe zimadziwonetsera okha nkhawa ndi kuvutika maganizo. M'mayesero ofanana omwewo, omwe anali ndi migraine adachepetsa kupweteka, nseru, kusanza, komanso kumva kuwala / phokoso mphindi 30 mutatha kugwiritsa ntchito chamomile oleogel (0.233 mg / g ya apigenin).

Apigenin amathanso kuyankha bwino pathupi pochepetsa cortisol, mahomoni opsinjika. Pamene maselo a adrenocortical aumunthu (in vitro) adawonetsedwa ndi mitundu yosiyanasiyana ya 12.5-100 μM ya flavonoid yomwe imaphatikizapo apigenin monga gawo, kupanga cortisol kunatsika mpaka 47.3% poyerekeza ndi maselo olamulira.
Mu mbewa, apigenin wotengedwa ku chomera Cephalotaxus sinensis wa banja la Plum Yew adawonetsa zotsutsana ndi matenda a shuga powonjezera kuyankha kwa thupi ku insulin. Zotsatirazi sizinafotokozedwebe mwa anthu, ngakhale mu kafukufuku yemwe adapatsa ophunzira chakumwa cha tsabola wakuda chomwe chinali ndi apigenin ndi chakudya chotsutsa mkate wa tirigu, shuga wamagazi ndi insulini sizinali zosiyana ndi gulu la zakumwa zoledzeretsa.
Mahomoni oberekera monga testosterone ndi estrogen amathanso kukhudzidwa ndi apigenin. M'maphunziro a preclinical, apigenin adasintha ma enzyme receptors ndi zochitika m'njira yomwe ikuwonetsa kuti zitha kukhudza zochita za testosterone, ngakhale zotsika kwambiri (5-10 μM).
Pa 20 μM, maselo a khansa ya m'mawere omwe amawonekera ku apigenin kwa maola 72 amasonyeza kulepheretsa kuchulukira mwa kulamulira ma estrogen receptors. Momwemonso, pamene ma cell a ovarian adakumana ndi apigenin (100 nM kwa maola 48) ofufuza adawona kuletsa kwa ntchito ya aromatase, yomwe imaganiziridwa kuti ndi njira yotheka popewa komanso kuchiza khansa ya m'mawere. Sizikudziwikabe, komabe, momwe zotsatirazi zingasinthire kukhala mlingo wapakamwa kuti munthu adye.

Kukhazikika kwa bioavailability ndi kukhazikika kwa flavonoid apigenin mwapayekha kumapangitsa kuti pakhale kafukufuku wamunthu molunjika pakudya kudzera muzomera, zitsamba, ndi zotulutsa zake. Kupezeka kwa bioavailability ndi kuyamwa kotsatira, ngakhale kuchokera ku mbewu ndi zakudya, kumathanso kusiyanasiyana pamunthu komanso komwe kumachokera. Kafukufuku wowunika kudya kwa flavonoid (kuphatikiza apigenin, yomwe imadziwika kuti flavone) komanso kutulutsa komwe kumayenderana ndi chiopsezo cha matenda, kungakhale njira yothandiza kwambiri yowunika. Kafukufuku wina wamkulu wowunikira, mwachitsanzo, adapeza kuti mwamagulu onse azakudya a flavonoid, kudya kwa apigenin kokha kunachepetsa 5% pachiwopsezo cha matenda oopsa kwa omwe adadya kwambiri, poyerekeza ndi omwe amadya zotsika kwambiri. Ngakhale zili choncho, pali kusiyana kwina komwe kungafotokoze mgwirizanowu, monga ndalama, zomwe zingakhudze thanzi labwino komanso mwayi wopeza chithandizo, zomwe zimapangitsa kuti chiopsezo cha matenda oopsa chichepetse. Kuyesera kumodzi mwachisawawa sikunapeze zotsatirapo pakati pa kudya zakudya zamtundu wa apigenin (anyezi ndi parsley) pazozindikiritsa zokhudzana ndi kuthamanga kwa magazi (mwachitsanzo, kuphatikiza kwa mapulateleti ndi zoyambira za njirayi). Chenjezo apa ndikuti plasma apigenin silingayesedwe m'magazi a omwe atenga nawo gawo, chifukwa chake kumwa kwanthawi yayitali komanso mosiyanasiyana kapenanso njira zosiyanasiyana, monga miyeso ya zotsatira zomwe sizimangoyang'ana kuphatikizika kwa mapulateleti, zitha kufunikira kuti mumvetsetse. zotsatira zomwe zingatheke.

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