Ni irihe sano riri hagati yubuzima bwabantu na apigenin?

Ubushakashatsi bw’inyamaswa bwerekana ko apigenine ishobora kubangamira ihinduka ry’imiterere y’imiterere iba mu ngirabuzimafatizo zanduye uburozi na bagiteri. [2] Apigenin irashobora kandi kugira uruhare rutaziguye mu gukuraho radicals yubuntu, kubuza imisemburo ikura y’ibibyimba, no kwinjiza imisemburo yangiza nka glutathione. [4] [5] [6] [7] Ubushobozi bwa Apigenin bwo kurwanya inflammatory bushobora kandi gusobanura ingaruka zabwo ku buzima bwo mu mutwe, imikorere y'ubwonko, ndetse no gukingira indwara, [8] [7] [10] [11]

Ibimenyetso bifatika byerekana ko apigenine ishobora kuba anti-okiside, anti-inflammatory, na / cyangwa uburyo bwo kurwanya indwara zanduza. Ingaruka za Apigenin zo kurwanya inflammatory (mubisanzwe zigaragara kuri 1-80 µM yibitekerezo) zishobora guturuka kubushobozi bwayo bwo guhagarika ibikorwa bya enzymes zimwe na zimwe (NO-synthase na COX2) na cytokine (interleukins 4, 6, 8, 17A, TNF-α ) bizwiho kugira uruhare mubisubizo bya inflammatory na allergic. Ku rundi ruhande, imiti igabanya ubukana bwa apigenin (100-279 µM / L) irashobora guterwa nubushobozi bwayo bwo gusiba radicals yubuntu no kurinda ADN kwangirika kwubusa.Apigenin irashobora kandi kuba umugereka wo gukumira ikwirakwizwa. ya parasite (5-25 μg / ml), mikorobe ya mikorobe (mM 1), na virusi (5-50μM), byerekana ko ishobora kuba ifite ubushobozi bwo kunoza kurwanya indwara.

Nubwo hari ibimenyetso bike by’amavuriro biboneka ku mikoranire ya apigenin n’ubuzima bw’ubudahangarwa, ibiriho birerekana ko hari anti-inflammatory anti-oxydeant, hamwe n’inyungu zo kurwanya kwandura binyuze mu kunoza ibikorwa bya enzyme ya antioxydeant, ibimenyetso byo gusaza, dermatite ya Atopic, parontontitis idakira, kandi bikagabanuka. ibyago byo kurwara diyabete yo mu bwoko bwa II. Twabibutsa ariko ko ibimenyetso byose byubuvuzi byerekana apigenin nkibigize isoko yabyo (urugero, ibimera, ibyatsi, nibindi) cyangwa nkibindi byongeweho, bityo izo ngaruka ntizishobora kwitirirwa apigenin yonyine.

Mu bushakashatsi bwibanze (inyamaswa n'utugingo ngengabuzima), apigenin yerekanye ingaruka ku guhangayika, neuroexcitation, na neurodegeneration.Mu bushakashatsi bwakozwe n'imbeba, ibipimo bya mg / kg 3-10 z'uburemere bw'umubiri byatumye kugabanuka guhangayika bidateye kwikinisha. Ingaruka za Neuroprotective, zitangwa binyuze mu kongera ubushobozi bwa mitochondial, nazo zagaragaye mu bushakashatsi bw’inyamaswa (1-33 μM).

Ubushakashatsi buke mubuvuzi busobanura ibisubizo mubantu. Babiri mu bushakashatsi butanga icyizere basuzumye apigenin nk'igice cya chamomile (Matricaria recutita) yo guhangayika na migraine. Igihe abitabiriye amahugurwa hamwe no gusuzuma indwara yo kwiheba no kwiheba bahawe mg 200-1000 mg ya chomomile ivamo buri munsi mu byumweru 8 (bigera kuri 1,2% apigenin), abashakashatsi babonye ko hari iterambere ryatewe no kwiyitaho no kwiheba. Mu igeragezwa risa naryo, abitabiriye migraine bagize igabanuka ry'ububabare, isesemi, kuruka, hamwe no kumva urumuri / urusaku nyuma yiminota 30 nyuma yo gukoresha oleogel ya chamomile (0.233 mg / g ya apigenine).

Apigenin irashobora kandi gutanga ibisubizo byiza bya physiologique mugabanya cortisol, imisemburo itesha umutwe. Iyo ingirabuzimafatizo ya adrenocortique yumuntu (muri vitro) yahuye nuruvange rwa 12.5-100 μM ya flavonoide ivanze na apigenin nkibigize, umusaruro wa cortisol wagabanutse kugera kuri 47.3% ugereranije ningirabuzimafatizo.
Imbeba, apigenin yakuwe mu gihingwa Cephalotaxus sinensis yo mu muryango wa Plum Yew yerekanye ibintu bimwe na bimwe birwanya diyabete mu kongera umubiri wa insuline. Ibisubizo ntabwo byigeze byigana mu bantu, nubwo mu bushakashatsi bwahaye abitabiriye ibinyobwa byitwa pepper yumukara birimo apigenin hamwe nifunguro ryumugati w ingano, glucose yamaraso na insuline ntaho byari bitandukaniye nitsinda rishinzwe kugenzura ibinyobwa.
Imisemburo yimyororokere nka testosterone na estrogene nayo ishobora kwanduzwa na apigenin. Mu bushakashatsi bwibanze, apigenin yahinduye reseptor ya enzyme n'ibikorwa muburyo bwerekana ko bishobora kugira ingaruka kubikorwa bya testosterone, kabone niyo byaba ari bike (5-10 μM).
Kuri 20 μM, selile ya kanseri yamabere yahuye na apigenin mumasaha 72 yerekanaga ikwirakwizwa ryinshi binyuze mugucunga reseptor ya estrogene. Mu buryo nk'ubwo, igihe intanga ngore zahuye na apigenine (100 nM mu masaha 48) abashakashatsi babonye ko ibikorwa bya aromatase bibujijwe, bikekwa ko ari uburyo bushoboka mu gukumira no kuvura kanseri y'ibere. Kugeza ubu ntibirasobanuka neza uburyo izo ngaruka zahindurwa mukanwa kanwa kugirango abantu barye.

Ibibazo bya bioavailable na stabilite ya flavonoid apigenin mu bwigunge bikunda kuvamo ubushakashatsi bwabantu hibandwa ku kurya binyuze mu bimera, ibimera, n’ibikomokaho. Bioavailability hamwe no kuyikuramo nyuma, ndetse bituruka ku bimera n’ibiribwa, birashobora kandi gutandukana kuri buri muntu ninkomoko yabyo. Ubushakashatsi busuzuma ibiryo bya flavonoide (harimo na apigenin, ishyirwa mu rwego rwa flavone) hamwe no gusohoka hamwe n’impanuka ziterwa n'indwara, birashobora rero kuba uburyo bwiza bwo gusuzuma. Ubushakashatsi bumwe bunini bwo kwitegereza, nk'urugero, bwagaragaje ko mu byiciro byose by’imirire ya flavonoide, gufata apigenine byonyine byagabanije 5% by’impanuka ziterwa na hypertension ku bitabiriye kurya byinshi, ugereranije n’abitabiriye kurya bike. Birashoboka nubwo, ko hari ibindi bitandukanye bishobora gusobanura iri shyirahamwe, nkamafaranga yinjiza, ashobora kugira ingaruka kumagara no kubona ubuvuzi, bigatuma ibyago bya hypertension bigabanuka. Ubushakashatsi bumwe bwateganijwe bwasanze nta ngaruka hagati yo kurya ibiryo bikungahaye kuri apigenin (igitunguru na parisile) kuri biomarkers zijyanye na hypertension (urugero, guteranya platine nababanjirije iki gikorwa). Icyifuzo hano ni uko plasma apigenin idashobora gupimwa mumaraso yabitabiriye, bityo rero igihe kirekire no kurya bitandukanye cyangwa wenda nuburyo butandukanye, nkingamba zagezweho zitibanda gusa ku guteranya platine, zishobora gukenerwa kugirango tubyumve ingaruka zishobora kubaho.

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[3]. Kuo ML, Lee KC, Lin JKGenotoxicities ya nitropyrenes no guhindurwa kwayo na apigenin, aside tannic, aside ellagic na indole-3-karbinol muri sisitemu ya Salmonella na CHO. Resut. (1992-Ugushyingo-16)
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[6]. H Wei, L Tye, E Bresnick, DF BirtInhibitori ya apigenin, igihingwa flavonoide, kuri epidermal ornithine decarboxylase hamwe no kuzamura ibibyimba byuruhu mu mbebaCancer Res. (1990 Gashyantare 1)
[7] .Gaur K, Siddique YH Ingaruka za apigenin ku ndwara zifata ubwonko.
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