Ndehupi hukama pakati pehutano hwevanhu neapigenin?

Zvidzidzo zvemhuka zvinoratidza kuti apigenin inogona kutadzisa kushanduka kwemajini kunoitika mumaseru anoiswa muchetura nemabhakitiriya.[2][3] Apigenin inogonawo kuita basa rakananga mukubvisa mahara radicals, kudziviswa kwemaenzayimu ekukura bundu, uye kupinza maenzayimu ekubvisa huturu akadai seglutathione.[4][5][6][7] Kugona kweApigenin kwekudzivirira kuzvimba kunogonawo kutsanangura mhedzisiro yayo pahutano hwepfungwa, kushanda kwehuropi, uye mhinduro yekudzivirira muviri, [8] [7] [10] [9] kunyangwe zvimwe zviongorori zvakakura zvisingatsigire mhedziso iyi maererano nemamiriro emetabolic. [11]

Preclinical humbowo hunoratidza kuti apigenin inogona kushanda se anti-oxidant, anti-inflammatory, uye/kana nzira yekuramba hutachiona hwepathogenic. Apigenin's anti-inflammatory effects (inowanzoonekwa pa 1-80 µM concentrations) inogona kubva pakukwanisa kwayo kudzvinyirira basa remamwe ma enzymes (NO-synthase uye COX2) uye cytokines (interleukins 4, 6, 8, 17A, TNF-α. ) izvo zvinozivikanwa kuti zvine chekuita nekuzvimba uye kusawirirana nemhinduro. Kune rumwe rutivi, apigenin's anti-oxidant properties (100-279 µM/L) inogona kunge yakakonzerwa nechikamu chekukwanisa kwayo kubvisa mahara radicals uye kudzivirira DNA kubva pakukuvadzwa kwemahara. yezvipembenene (5-25 μg/ml), microbial biofilms (1 mM), uye mavhairasi (5-50μM), zvichiratidza kuti inogona kunge iine mukana wekuvandudza kuramba hutachiona.

Kunyangwe paine humbowo hudiki hwekiriniki hunowanikwa pakudyidzana kweapigenin nehutano hwekudzivirira zvirwere, zviripo zvinoratidza mamwe anti-inflammatory anti-oxidant, uye kutapukira kunobatsira kuburikidza nekuvandudzwa kwe antioxidant enzyme basa, zviratidzo zvekuchembera, atopic dermatitis, chronic periodontitis, uye kuderedzwa. njodzi yechirwere cheshuga chechipiri. Izvo zvinofanirwa kucherechedzwa, zvisinei, kuti humbowo hwekiriniki hunotsvaga apigenin sechikamu chekwakabva (semuenzaniso, zvirimwa, miriwo, nezvimwewo) kana sechinhu chakawedzerwa, saka izvi zvinokonzeresa hazvigone kunzi kune apigenin chete.

Muzvidzidzo zvepreclinical (mhuka nesero), apigenin yakaratidza zvinokonzeresa kufunganya, kutsamwisa, uye kuora mwoyo.Muchidzidzo chembeva, kuyerwa kwe3–10 mg/kg yehuremu hwemuviri kwakaburitsa kudzikisira mukufunganya pasina kukonzeresa. [2] Neuroprotective mhedzisiro, yakapihwa kuburikidza nekuwedzera mitochondrial kugona, yakaonekwawo mune zvidzidzo zvemhuka (1-33 μM).

Zvidzidzo zvishoma zvekiriniki zvinoshandura mhedzisiro iyi kuva vanhu. Zviviri zvezvidzidzo zvinonyanya kuvimbisa zvakaongorora apigenin sechikamu chechamomile (Matricaria recutita) yekushushikana uye migraine. Apo vatori vechikamu vane-co-diagnoses yekuzvidya mwoyo uye kuora mwoyo vakapiwa 200-1,000 mg yechamomile yakatorwa pazuva kwemavhiki masere (yakaenzana kusvika ku1.2% apigenin), vatsvakurudzi vakaona kuvandudzwa kwezviyero zvekuzvidya mwoyo uye kuora mwoyo zviyero. Muchiitiko chakafanana chekuyambuka, vatori vechikamu vane migraine vakawana kuderedzwa kwemarwadzo, kusvotwa, kurutsa, uye chiedza / ruzha senitivity 30 maminitsi mushure mekushandiswa kwechamomile oleogel (0.233 mg / g ye apigenin).

Apigenin inogona zvakare kukwanisa kuita zvakanaka physiologic mhinduro nekudzikisa cortisol, iyo inoshungurudza hormone. Apo masero evanhu adrenocortical (in vitro) akaonekwa kune zvakasiyana-siyana zve 12.5-100 μM flavonoid misanganiswa yaisanganisira apigenin sechikamu, kugadzirwa kwecortisol kwakaderera kusvika ku47.3% kana ichienzaniswa nemasero ekudzora.
Mumakonzo, apigenin yakatorwa kubva muchirimwa Cephalotaxus sinensis yemhuri yePlum Yew yakaratidza mamwe anti-diabetic maitiro nekuwedzera physiologic mhinduro kune insulin. Izvi zvigumisiro hazvisati zvadzokororwa muvanhu, kunyange mune chidzidzo chakapa vatori vechikamu chinwiwa chepepuru tsvuku chaiva neapigenin uye chingwa chegorosi dambudziko rekudya, shuga yeropa uye insulin zvakanga zvisina kusiyana neboka rekunwa doro.
Mahomoni ekubereka akadai se testosterone uye estrogen anogonawo kukanganiswa neapigenin. Muzvidzidzo zvepamberi, apigenin yakagadziridzwa enzyme receptors uye chiitiko nenzira inoratidza kuti inogona kukanganisa basa re testosterone, kunyangwe iri yakaderera (5-10 μM) huwandu.
Pa 20 μM, masero emukenza wezamu akaiswa kune apigenin kwemaawa makumi manomwe nemaviri akaratidza kudziviswa kupararira kuburikidza nekutonga kweestrogen receptors. Saizvozvo, apo masero ovarian akaiswa kune apigenin (100 nM kwemaawa makumi mana nemasere) vaongorori vakacherekedza inhibition yearomatase chiitiko, iyo inofungidzirwa kuti ndiyo inogoneka nzira mukudzivirira nekurapa kenza yemazamu. Izvo hazvisati zvanyatsojeka, zvisinei, kuti izvi zvinokonzeresa zvingashandukira sei kuita remuromo dosi rekudyiwa kwevanhu.

Iyo bioavailability uye kugadzikana nyaya dzeflavonoid apigenin mukuzviparadzanisa zvinowanzokonzera tsvagiridzo yemunhu ine tarisiro yekudyiwa kuburikidza nezvirimwa, miriwo, uye zvinyorwa zvadzo. Bioavailability uye kunotevera kunyudzwa, kunyangwe kubva kuchirimwa uye chikafu masosi, inogona zvakare kusiyana pamunhu uye kwainobva kwairi. Zvidzidzo zvekuongorora kudya kweflavonoid kudya (kusanganisira apigenin, iyo inonzi sub-classed se flavone) uye kubuda pamwe chete nengozi yechirwere, inogona kunge iri nzira inonyanya kushandiswa yekuongorora. Imwe huru yekuongorora yekuongorora, semuenzaniso, yakawana kuti pane zvese zvekudya zveflavonoid subclass, kudyiwa kweapigenin chete kwakatakura kuderedzwa kwe5% mungozi yehypertension kune vatori vechikamu vakadya zvakanyanya, zvichienzaniswa nevatori vechikamu vanodya yakaderera. Zvinogoneka hazvo, kuti kune mimwe misiyano inogona kutsanangura kushamwaridzana uku, semari inowanikwa, inogona kukanganisa hutano uye kuwana rubatsiro, zvichikonzera kudzikiswa kwenjodzi yehypertension. Imwe ongororo yakasarudzika haina mhedzisiro pakati pekudyiwa kweapigenin chikafu chakapfuma (hanyanisi neparsley) pane biomarkers zvine chekuita nehypertension (semuenzaniso, kuunganidzwa kweplatelet uye precursors yeichi chiitiko). Caveat pano ndeyekuti plasma apigenin haigone kuyerwa muropa revatori vechikamu, saka nguva yakareba uye kushandiswa kwakasiyana-siyana kana zvimwe nzira dzakasiyana, senge mhedzisiro nhanho dzisingatarise chete kuunganidzwa kweplatelet, inogona kudiwa kuti unzwisise. zvinogona kuitika.

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