Waa maxay xiriirka ka dhexeeya caafimaadka aadanaha iyo apigenin?

Cilmi-baadhisyada xayawaanku waxay soo jeedinayaan in apigenin laga yaabo inay carqaladayso isbeddellada hidde-sideyaasha ee ka dhaca unugyada soo gaadha sunta iyo bakteeriyada.[2][3] Apigenin waxa kale oo laga yaabaa inay door toos ah ka ciyaarto ka saarida xagjirnimada xorta ah, ka hortagga enzymes koritaanka burada, iyo kicinta enzymes sun-saarista sida glutathione.[4][5][6] Awoodda anti-bararka ee Apigenin ayaa sidoo kale sharxi karta saameynta ay ku leedahay caafimaadka maskaxda, shaqada maskaxda, iyo jawaabta difaaca jirka, [8] [7] [10] [9] inkastoo qaar ka mid ah daraasadaha indha-indheynta ee waaweyn aysan taageerin gunaanadkan marka la eego xaaladaha dheef-shiid kiimikaadka. [11]

Caddaynta hore waxay soo jeedinaysaa in apigenin laga yaabo inay u adeegto sida anti-oxidant, ka-hortagga bararka, iyo/ama macnaheedu yahay in laga hortago caabuqa pathogenic. Saamaynta anti-bararka ee Apigenin (sida caadiga ah lagu arko 1-80 µM uruurinta) ayaa laga yaabaa inay ka soo baxdo awoodda ay u leedahay inay xakameyso waxqabadka enzymes qaarkood (NO-synthase iyo COX2) iyo cytokines (interleukins 4, 6, 8, 17A, TNF-α). ) kuwaas oo la og yahay inay ku lug leeyihiin jawaabaha bararka iyo xasaasiyadda. Dhanka kale, guryaha apigenin ee ka-hortagga oksidant (100-279 µM/L) waxaa laga yaabaa inay qayb ahaan sabab u tahay awoodda ay u leedahay in ay iska saarto xagjirrada xorta ah iyo ka ilaalinta DNA-da waxyeellada xagjirka bilaashka ah. dulin (5-25 μg/ml), biofilms microbial (1 mM), iyo fayrasyada (5-50μM), taasoo soo jeedinaysa inay yeelan karto awood lagu wanaajiyo iska caabinta caabuqa.

In kasta oo ay jiraan caddayn caafimaad oo yar oo laga heli karo isdhexgalka apigenin ee caafimaadka difaaca, waxa hadda jira ayaa soo jeedinaya qaar ka mid ah anti-bararka anti-oxidant, iyo faa'iidooyinka caabbinta caabuqa iyada oo loo marayo hagaajinta waxqabadka enzyme antioxidant, calaamadaha gabowga, dermatitis atopic, periodontitis dabadheeraad ah, iyo hoos u dhigista. halista nooca II ee sonkorowga. Waa in la ogaadaa, si kastaba ha ahaatee, in dhammaan caddaymaha kiliinikada ay sahamiyaan apigenin sida qayb ka mid ah isha (tusaale, dhirta, geedo yaryar, iwm.) ama sida walaxda lagu daray, sidaas darteed saameyntan looma nisbayn karo apigenin oo keliya.

Daraasadaha hore ee (xayawaanka iyo unugga), apigenin waxay soo bandhigtay saamaynta walaaca, neuroexcitation, iyo neurodegeneration. Daraasadda jiirka, qiyaasta 3-10 mg / kg ee miisaanka jidhka waxay soo saartay hoos u dhigista walaaca iyada oo aan keenin suuxdin. Saamaynta Neuroprotective, oo lagu bixiyo awoodda mitochondrial oo kordhay, ayaa sidoo kale lagu arkay daraasadaha xayawaanka (1-33 μM).

Daraasado caafimaad oo tiro yar ayaa natiijooyinkan u tarjuma aadanaha. Laba ka mid ah cilmi-baarisyada ugu rajo-gelinta badan ayaa baaray apigenin oo ah qayb ka mid ah chamomile (Matricaria recutita) ee welwelka iyo madax-xanuunka. Marka ka qaybgalayaasha la wadaago xanuunka welwelka iyo niyad-jabka ayaa la siiyay 200-1,000 mg oo chamomile ah maalintiiba toddobaadyada 8 (oo loo qoondeeyay 1.2% apigenin), cilmi-baarayaashu waxay arkeen hagaajinta walaaca is-sheegida iyo miisaanka niyad-jabka. Tijaabo isku-dhafan oo la mid ah, ka-qaybgalayaasha qaba xanuunka dhanjafka waxay la kulmeen hoos u dhac ku yimaada xanuunka, lallabbo, matag, iyo dareenka iftiinka / qaylada 30 ka dib markii la isticmaalo chamomile oleogel (0.233 mg / g of apigenin).

Apigenin waxa kale oo laga yaabaa in uu sameeyo jawaabaha jireed ee wanaagsan iyada oo la yareeyo cortisol, hormoonka walaaca. Marka unugyada adrenocortical ee bini'aadamka (in vitro) lagu soo bandhigo noocyo kala duwan oo ah 12.5-100 μM flavonoids oo ay ku jiraan apigenin qayb ahaan, wax soo saarka cortisol ayaa hoos u dhacay ilaa 47.3% marka la barbardhigo unugyada kantaroolka.
Jiirarka, apigenin laga soo saaray geedka Cephalotaxus sinensis ee qoyska Plum Yew waxay muujisay qaar ka mid ah guryaha ka hortagga sokorowga iyadoo la kordhinayo jawaabta jireed ee insulinta. Natiijooyinkan weli laguma soo celin bini'aadamka, inkastoo daraasad siisay ka qaybgalayaasha cabitaanka basbaaska madow ee ka kooban apigenin iyo cunto adag oo rooti ah, gulukooska dhiigga iyo insulinta kama duwana kooxda cabitaanka khamriga.
Hormoonnada taranka sida testosterone iyo estrogen ayaa sidoo kale laga yaabaa inay saameyso apigenin. Daraasadaha hore ee daaweynta, apigenin ayaa wax ka beddelay enzymes reseptors iyo dhaqdhaqaaqa hab soo jeedinaya inay saameyn ku yeelan karto dhaqdhaqaaqa testosterone, xitaa qadar yar (5-10 μM).
Markay tahay 20 μM, unugyada kansarka naasaha ee loo soo bandhigo apigenin saacadaha 72 waxay muujiyeen kororka xannibaadda iyada oo loo marayo xakamaynta soo-dhoweynta estrogen. Sidoo kale, markii unugyada ugxan-sidaha loo soo bandhigo apigenin (100 nM saacadaha 48) cilmi-baarayaashu waxay arkeen xannibaadda dhaqdhaqaaqa aromatase, taas oo loo maleynayo inay tahay habka suurtogalka ah ee ka hortagga iyo daaweynta kansarka naasaha. Ilaa hadda ma cadda, si kastaba ha ahaatee, sida saamayntani ay ugu tarjumi karto qiyaasta afka ee isticmaalka aadanaha.

Arrimaha noolaha iyo xasiloonida flavonoid apigenin ee go'doominta waxay u janjeertaa inay ka dhalato cilmi baarista bini'aadamka iyadoo diiradda la saarayo isticmaalka dhirta, geedo yaryar, iyo soosaarkooda. Bioavailability iyo nuugista ku xigta, xitaa laga helo dhirta iyo ilaha cuntada, waxay sidoo kale ku kala duwanaan kartaa shaqsi kasta iyo isha ay ka timid. Daraasadaha lagu baarayo qaadashada flavonoid-ka cuntada (ay ku jirto apigenin, oo loo kala soocay sida flavone) iyo qashin-saarka oo ay weheliso khatarta cudurrada, ayaa laga yaabaa inay noqoto habka ugu waxtarka badan ee qiimeynta. Mid ka mid ah daraasad ballaadhan oo indho-indhayn ah, tusaale ahaan, ayaa lagu ogaaday in dhammaan heerarka flavonoid-ka ee cuntada, qaadashada apigenin oo keliya ay 5% hoos u dhigtay khatarta dhiig-karka ee ka-qaybgalayaasha isticmaala qadarka ugu sarreeya, marka la barbardhigo ka qaybgalayaasha oo isticmaalaya kuwa ugu hooseeya. Waxaa suurtogal ah in kastoo, ay jiraan kala duwanaansho kale oo sharxi kara ururkan, sida dakhliga, kaas oo saameyn kara xaaladda caafimaadka iyo helitaanka daryeelka, taasoo keenta khatarta dhiig-karka. Hal tijaabo oo la kala soocay ayaan wax saamayn ah ku yeelan inta u dhaxaysa isticmaalka cuntooyinka hodanka ah ee apigenin (basal iyo dhir) ee biomarkers ee la xidhiidha dhiig-karka (tusaale, isu-geynta platelets iyo horudhacayaasha habkan). Digniintu waa in plasma apigenin aan lagu cabbiri karin dhiigga ka qaybgalayaasha, muddada dheer iyo isticmaalka kala duwan ama laga yaabee xitaa habab kala duwan, sida cabbirrada natiijada ee aan diiradda saarayn isku-darka platelet, ayaa loo baahan karaa si loo fahmo. saamaynta iman kara.

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