Kamano ke efe lipakeng tsa bophelo bo botle ba motho le apigenin?

Lithuto tsa liphoofolo li fana ka maikutlo a hore apigenin e ka sitisa liphetoho tsa lefutso tse hlahang liseleng tse pepesehileng chefo le baktheria.[2][3] Apigenin e ka boela ea phetha karolo e tobileng ho tloseng ha li-radicals tsa mahala, ho thibela li-enzyme tsa ho hōla ha hlahala, le ho kenngoa ha li-enzyme tsa ho tlosa chefo tse kang glutathione.[4][5][6][7] Bokhoni ba Apigenin ba ho thibela ho ruruha bo ka boela ba hlalosa litlamorao tsa eona ho bophelo bo botle ba kelello, tšebetso ea boko, le karabelo ea 'mele ea ho itšireletsa mafung, [8][7][10][9] leha lithuto tse ling tse kholo tsa tlhahlobo li sa tšehetse qeto ena mabapi le maemo a metabolism. [11]

Bopaki ba preclinical bo fana ka maikutlo a hore apigenin e ka sebetsa e le anti-oxidant, anti-inflammatory, le/kapa mokhoa oa ho hanela tšoaetso ea pathogenic. Liphello tse khahlanong le ho ruruha tsa Apigenin (tseo hangata li bonoang ho 1-80 μM concentrations) li ka 'na tsa tsoa ho bokhoni ba eona ba ho thibela mosebetsi oa li-enzyme tse ling (NO-synthase le COX2) le li-cytokines (interleukins 4, 6, 8, 17A, TNF-α). ) tse tsejoang e le tse amehang karabelong ea ho ruruha le ea ho hana. Ka lehlakoreng le leng, thepa ea anti-oxidant ea apigenin (100-279 µM/L) e ka 'na ea bakoa ke bokhoni ba eona ba ho senya li-radicals tsa mahala le ho sireletsa DNA tšenyo e sa lefelloeng. ea likokoana-hloko (5-25 μg/ml), microbial biofilms (1 mM), le likokoana-hloko (5-50μM), e fana ka maikutlo a hore e ka ba le monyetla oa ho ntlafatsa ho hanyetsa tšoaetso.

Leha ho na le bopaki bo fokolang ba kliniki bo fumanehang mabapi le tšebelisano ea apigenin le bophelo bo botle ba 'mele, se teng se fana ka maikutlo a anti-inflammatory anti-oxidant, le melemo ea ho hanyetsa ts'oaetso ka ntlafatso ea ts'ebetso ea enzyme ea antioxidant, matšoao a botsofali, atopic dermatitis, periodontitis e sa foleng, le ho fokotseha. kotsi ea lefu la tsoekere la mofuta oa II. Leha ho le joalo, hoa lokela ho hlokomeloa hore bopaki bohle ba kliniki bo hlahloba apigenin e le karolo ea mohloli oa eona (mohlala, limela, litlama, joalo-joalo) kapa e le motsoako o eketsehileng, kahoo liphello tsena li ke ke tsa amahanngoa le apigenin feela.

Lithutong tsa preclinical (phoofolo le lisele), apigenin e bontšitse litlamorao ho matšoenyeho, neuroexcitation, le neurodegeneration. Phuputsong ea litoeba, litekanyetso tsa 3-10 mg/kg tsa boima ba 'mele li hlahisitse phokotseho ea ho tšoenyeha ntle le ho baka khutso.[2] Liphello tsa Neuroprotective, tse fanoeng ka ho eketseha ha matla a mitochondrial, li boetse li bonoa lithutong tsa liphoofolo (1-33 μM).

Lithuto tse fokolang tsa bongaka li fetolela liphetho tsena ho batho. Lithuto tse peli tse tšepisang haholo li ile tsa hlahloba apigenin e le motsoako oa chamomile (Matricaria recutita) bakeng sa matšoenyeho le migraine. Ha barupeluoa ba nang le li-co-diagnoses tsa ho tšoenyeha le ho tepella maikutlong ba fuoa 200-1,000 mg ea chamomile ka letsatsi bakeng sa libeke tsa 8 (e tloaelehileng ho 1.2% apigenin), bafuputsi ba ile ba hlokomela ntlafatso ea ho tšoenyeha ho iponahatsang le sekala sa khatello ea maikutlo. Tekong e ts'oanang ea ho tšela, barupeluoa ba nang le migraine ba ile ba fokotsa bohloko, ho nyekeloa ke pelo, ho hlatsa, le kutloisiso e khanyang / lerata metsotso ea 30 ka mor'a tšebeliso ea chamomile oleogel (0.233 mg / g ea apigenin).

Apigenin e ka boela ea khona ho fana ka likarabo tse ntle tsa physiologic ka ho fokotsa cortisol, hormone ea khatello ea kelello. Ha lisele tsa adrenocortical tsa motho (in vitro) li ne li pepesehetse mefuta e mengata ea 12.5-100 μM ea metsoako ea flavonoid e kenyeletsang apigenin e le karolo, tlhahiso ea cortisol e fokotsehile ho fihlela ho 47.3% ha e bapisoa le lisele tsa taolo.
Ho litoeba, apigenin e ntšitsoeng semeleng Cephalotaxus sinensis ea lelapa la Plum Yew e bonts'itse litšobotsi tse ling tsa anti-diabetic ka ho eketsa karabelo ea 'mele ho insulin. Liphello tsena ha li e-s'o ka li phetoa ho batho, le hoja phuputsong e ileng ea fa barupeluoa seno sa pepere e ntšo se nang le apigenin le phephetso ea bohobe ba koro, tsoekere ea mali le insulin li ne li sa fapane le sehlopha sa lino tse tahang.
Lihomone tsa ho ikatisa tse kang testosterone le estrogen le tsona li ka ’na tsa angoa ke apigenin. Lithutong tsa pele, apigenin e fetotse li-receptor tsa enzyme le ts'ebetso ka tsela e bonts'ang hore e ka ama ts'ebetso ea testosterone, leha e le ka bongata bo tlase (5-10 μM).
Ka 20 μM, lisele tsa kankere ea matsoele tse pepesehetseng apigenin bakeng sa lihora tsa 72 li bontšitse ho ata ho thibetsoeng ka ho laola li-receptor tsa estrogen. Ka mokhoa o ts'oanang, ha lisele tsa mahe a bomme li ne li pepesehetse apigenin (100 nM bakeng sa lihora tse 48) bafuputsi ba ile ba bona thibelo ea ts'ebetso ea aromatase, eo ho nahanoang hore ke mokhoa o ka khonehang oa ho thibela le ho phekola mofetše oa matsoele. Leha ho le joalo, ha ho tsejoe hantle hore na litlamorao tsena li ka fetoha joang hore motho a sebelisoe ka molomo.

Litaba tsa bioavailability le botsitso ba flavonoid apigenin ka thoko li atisa ho fella ka lipatlisiso tsa batho tse tsepamisitseng maikutlo ho sebelisoa ka limela, litlama le lihlahisoa tsa tsona. Bioavailability le ho monya ho latelang, esita le mehloling ea limela le lijo, le tsona li ka fapana ho ea ka motho ka mong le mohloli oo e tsoang ho ona. Liphuputso tse hlahlobang ho ja flavonoid ea lijo (ho kenyeletsoa apigenin, e nkoang e le flavone) le ho tsoa ka ntle ho kotsi ea mafu, ka hona e ka 'na ea e-ba mokhoa o sebetsang ka ho fetisisa oa tlhahlobo. Phuputso e 'ngoe e kholo ea ho shebella, mohlala, e fumane hore ho lihlopha tsohle tsa lijo tsa flavonoid, ho noa apigenin feela ho na le phokotso ea 5% ea kotsi ea khatello ea mali ho barupeluoa ba jang chelete e ngata ka ho fetisisa, ha ba bapisoa le barupeluoa ba jang tlaase ka ho fetisisa. Leha ho le joalo, ho ka etsahala hore ho na le liphapang tse ling tse ka hlalosang mokhatlo ona, joalo ka chelete e kenang, e ka amang boemo ba bophelo bo botle le ho fumana tlhokomelo, e leng se lebisang ho fokotseng kotsi ea khatello ea mali. Teko e le 'ngoe e sa reroang ha ea ka ea fumana phello lipakeng tsa tšebeliso ea lijo tse ruileng tsa apigenin (eie le parsley) ho li-biomarker tse amanang le khatello ea mali (mohlala, ho bokellana ha liplatelete le li-precursors tsa ts'ebetso ena). Tlhokomeliso mona ke hore plasma apigenin e ne e ke ke ea lekanyetsoa maling a barupeluoa, kahoo tšebeliso ea nako e telele le e fapaneng kapa mohlomong le mekhoa e fapaneng, joalo ka mehato ea sephetho e sa tsepamiseng feela ho bokellana ha platelet, ho ka hlokahala ho utloisisa. liphello tse ka bang teng.

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