Yintoni ubudlelwane phakathi kwempilo yomntu kunye ne-apigenin?

Uphononongo lwezilwanyana lucebisa ukuba i-apigenin inokuthintela utshintsho lwemfuza olwenzeka kwiiseli ezisesichengeni setyhefu kunye neentsholongwane. [2][3] I-Apigenin inokuphinda idlale indima ethe ngqo ekususeni i-radicals yamahhala, inhibition ye-enzymes yokukhula kwethumba, kunye nokungeniswa kwee-enzymes ze-detoxification ezifana ne-glutathione.[4][5][6][7] Isakhono se-Apigenin sokuchasa ukudumba sinokuchaza iziphumo zayo kwimpilo yengqondo, ukusebenza kwengqondo, kunye nempendulo ye-immunological, [8][7][10][9] nangona ezinye iiphononongo ezinkulu zoqwalaselo zingasixhasi esi sigqibo malunga neemeko zemetabolism. [11]

Ubungqina be-preclinical bubonisa ukuba i-apigenin inokusebenza njenge-anti-oxidant, i-anti-inflammatory, kunye / okanye indlela yokumelana nosulelo lwe-pathogenic. I-Apigenin's anti-inflammatory effects (ebonwa ngokubanzi kwi-1-80 µM concentrations) inokufumaneka kwikhono layo lokucinezela umsebenzi wezinye i-enzymes (NO-synthase kunye ne-COX2) kunye ne-cytokines (interleukins 4, 6, 8, 17A, TNF-α ) ezaziwayo ukuba zibandakanyeka kwiimpendulo ezivuthayo kunye ne-aleji. Ngakolunye uhlangothi, iipropathi ze-apigenin ezichasene ne-oxidant (100-279 µM/L) zisenokuba ngenxa yokukwazi ukukhupha iiradicals zamahhala kunye nokukhusela i-DNA kumonakalo omkhulu. iiparasites (5-25 μg/ml), i-microbial biofilms (1 mM), kunye neentsholongwane (5-50μM), ebonisa ukuba inokuba namandla okuphucula ukuxhathisa usulelo.

Nangona kukho ubungqina obuncinane beklinikhi obukhoyo ekusebenzisaneni kwe-apigenin kunye nempilo yomzimba, yintoni ekhoyo ibonisa ukuba i-anti-inflammatory anti-oxidant, kunye neenzuzo zokuchasana nosulelo ngokuphucula umsebenzi we-antioxidant enzyme, iimpawu zokuguga, i-atopic dermatitis, i-periodontitis engapheliyo, kunye nokunciphisa. umngcipheko wohlobo lwe-II yeswekile. Kufuneka kuqatshelwe, nangona kunjalo, ukuba bonke ubungqina beklinikhi buhlola i-apigenin njengenxalenye yomthombo wayo (umzekelo, izityalo, izityalo, njl.)

Kwizifundo zangaphambi kweklinikhi (izilwanyana kunye neeseli), i-apigenin ibonise iziphumo kwixhala, i-neuroexcitation, kunye ne-neurodegeneration.Kuphononongo lwe-mouse, iidosi ze-3-10 mg / kg zobunzima bomzimba zivelise ukunciphisa ixhala ngaphandle kokubangela ukuthotywa. Iziphumo ze-neuroprotective, ezinikezelwa ngokunyuka kwamandla e-mitochondrial, ziye zabonwa kwizifundo zezilwanyana (1-33 μM).

Zimbalwa izifundo zeklinikhi eziguqulela ezi ziphumo ebantwini. Izifundo ezimbini ezithembisayo zivavanye i-apigenin njengenxalenye ye-chamomile (i-Matricaria recutita) yokukhathazeka kunye ne-migraine. Xa abathathi-nxaxheba abane-co-diagnoses yokuxhalaba kunye nokudandatheka banikwa i-200-1,000 mg ye-chamomile extract ngosuku kwiiveki ze-8 (ezisemgangathweni kwi-1.2% ye-apigenin), abaphandi baqaphela ukuphuculwa kwe-self-reported ixhala kunye nezikali zokudandatheka. Kwilingo elifanayo lokuwela, abathathi-nxaxheba abane-migraine bafumana ukunciphisa intlungu, isicathulo, ukuhlanza, kunye nokukhanya / ukuvakala kwengxolo imizuzu engama-30 emva kokusetyenziswa kwe-chamomile oleogel (0.233 mg / g ye-apigenin).

I-Apigenin inokukwazi ukusebenzisa iimpendulo eziphilileyo ze-physiologic ngokunciphisa i-cortisol, ihomoni yoxinzelelo. Xa iiseli ze-adrenocortical zabantu (in vitro) zibonakaliswe kuluhlu lwe-12.5-100 μM imixube ye-flavonoid equka i-apigenin njengenxalenye, imveliso ye-cortisol yehla ukuya kwi-47.3% xa kuthelekiswa neeseli zokulawula.
Kwiimpuku, i-apigenin ekhutshwe kwisityalo iCephalotaxus sinensis yosapho lwePlum Yew ibonise iipropathi ezithile ezichasene nesifo seswekile ngokunyusa impendulo ye-physiologic kwi-insulin. Ezi ziphumo azikacaciswanga kubantu, nangona kuphononongo olwanika abathathi-nxaxheba isiselo esiphundu se-pepper esine-apigenin kunye nesonka sesonka sengqolowa yokutya, i-blood glucose kunye ne-insulin yayingafani neqela lokulawula isiselo.
Iihomoni zokuzala ezifana ne-testosterone kunye ne-estrogen zinokuchatshazelwa yi-apigenin. Kwizifundo zangaphambi kweklinikhi, i-apigenin iguqule i-enzyme receptors kunye nomsebenzi ngendlela ebonisa ukuba inokuchaphazela umsebenzi we testosterone, nakwixabiso eliphantsi (5-10 μM).
Kwi-20 μM, iiseli zomhlaza wesifuba ezivezwe kwi-apigenin kwiiyure ze-72 zibonise ukwanda okuvinjelwe ngokulawulwa kwe-estrogen receptors. Ngokufanayo, xa iiseli ze-ovarian zibonakaliswe kwi-apigenin (i-100 nM kwiiyure ze-48) abaphandi baqaphela ukuvinjelwa komsebenzi we-aromatase, ekucingelwa ukuba yindlela enokwenzeka yokuthintela kunye nonyango lomhlaza webele. Akukacaci, nangona kunjalo, ukuba ezi ziphumo zingaguqulelwa njani kwidosi yomlomo ukuze isetyenziswe ngabantu.

Imiba ye-bioavailability kunye nokuzinza kwe-flavonoid apigenin ngokuzimeleyo ithambekele ekubangeleni uphando lwabantu ngokugxila ekusetyenzisweni ngokusebenzisa izityalo, imifuno, kunye nezicatshulwa zabo. I-Bioavailability kunye nokufunxwa okulandelayo, nakwimithombo yezityalo kunye nokutya, kunokwahluka kumntu ngamnye kunye nomthombo ophuma kuwo. Izifundo ezivavanya ukutya kwe-flavonoid (kubandakanywa ne-apigenin, ephantsi kwe-flavone) kunye nokukhupha kunye nomngcipheko wesifo, ngoko ke ingaba yeyona ndlela isebenzayo yokuhlola. Olunye uphononongo olukhulu lokuqwalasela, umzekelo, lufumene ukuba kuzo zonke ii-subclasses ze-flavonoid zokutya, ukuthathwa kwe-apigenin yodwa kuthathe ukunciphisa i-5% kumngcipheko we-hypertension kubathathi-nxaxheba abadla amanani aphezulu, xa kuthelekiswa nabathathi-nxaxheba abasebenzisa i-lowest. Nangona kunjalo, kunokwenzeka ukuba kukho ezinye iiyantlukwano ezinokuthi zichaze lo mbutho, njengengeniso, enokuchaphazela isimo sempilo kunye nokufikelela ekunyamekelweni, okukhokelela ekunciphiseni umngcipheko we-hypertension. Olunye uvavanyo olungenamkhethe alufumananga siphumo phakathi kokusetyenziswa kokutya okutyebileyo kwe-apigenin (i-anyanisi kunye ne-parsley) kwiimpawu ze-biomarkers ezinxulumene noxinzelelo lwegazi (umzekelo, ukuhlanganiswa kweeplatelet kunye ne-precursors yale nkqubo). I-caveat apha kukuba i-plasma apigenin ayinakulinganiswa kwigazi labathathi-nxaxheba, ngoko ke ixesha elide kunye nokusetyenziswa okuhlukeneyo okanye mhlawumbi iindlela ezahlukeneyo, ezifana nemilinganiselo yesiphumo engagxininisi kuphela kwi-platelet aggregation, inokufuneka ukuze uqonde. iziphumo ezinokubakho.

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