Buyini ubudlelwano phakathi kwempilo yomuntu ne-apigenin?

Ucwaningo lwezilwane luphakamisa ukuthi i-apigenin ingase ivimbe ukuguqulwa kofuzo okwenzeka kumaseli achayeka ebuthini namagciwane.[2][3] I-Apigenin ingase futhi idlale indima eqondile ekukhipheni ama-radicals mahhala, ukuvimbela ama-enzyme okukhula kwesimila, kanye nokungeniswa kwama-enzyme e-detoxification afana ne-glutathione.[4][5][6][7] Ikhono le-Apigenin lokuqeda ukuvuvukala lingase lichaze imiphumela yalo empilweni yengqondo, ukusebenza kobuchopho, kanye nokusabela kokuzivikela komzimba, [8][7][10][9] nakuba ezinye izifundo zokuqaphela ezinkulu zingasisekeli lesi siphetho mayelana nezimo ze-metabolic. [11]

Ubufakazi bangaphambi komtholampilo bubonisa ukuthi i-apigenin ingase isebenze njenge-anti-oxidant, anti-inflammatory, kanye/noma izindlela zokumelana nokutheleleka kwe-pathogenic. Imiphumela elwa nokuvuvukala ye-Apigenin (evame ukubonakala ekugxilweni kwe-1-80 µM) ingase ithathwe ekhonweni layo lokucindezela umsebenzi wamanye ama-enzyme (NO-synthase ne-COX2) nama-cytokines (interleukins 4, 6, 8, 17A, TNF-α ) ezaziwa ngokubandakanyeka ekuphenduleni ukuvuvukala kanye nokungezwani komzimba. Ngakolunye uhlangothi, izakhiwo ze-apigenin ezilwa ne-oxidant (100-279 µM/L) kungenzeka ngenxa yengxenye yekhono layo lokususa ama-radicals mahhala kanye nokuvikela i-DNA emonakalweni wamahhala. Izimuncagazi (5-25 μg/ml), i-microbial biofilms (1 mM), kanye namagciwane (5-50μM), okuphakamisa ukuthi ingase ibe namandla okuthuthukisa ukumelana nokutheleleka.

Nakuba kunobufakazi obuncane bomtholampilo obutholakala ekusebenzelaneni kwe-apigenin nempilo yokuzivikela komzimba, okukhona kuphakamisa izinzuzo ezithile zokulwa nokuvuvukala, kanye nezinzuzo zokumelana nokutheleleka ngokuthuthukiswa komsebenzi wama-enzyme e-antioxidant, izimpawu zokuguga, i-atopic dermatitis, i-periodontitis engapheli, nokuncipha. ingozi yohlobo lwesifo sikashukela sohlobo II. Nokho, kufanele kuqashelwe ukuthi bonke ubufakazi bomtholampilo buhlola i-apigenin njengengxenye yomthombo wayo (isb, izitshalo, amakhambi, njll.) noma njengesithako esengeziwe, ngakho-ke le miphumela ayikwazi ukubhekwa njenge-apigenin yodwa.

Ocwaningweni lwangaphambi komtholampilo (isilwane neseli), i-apigenin ibonise imiphumela yokukhathazeka, i-neuroexcitation, kanye ne-neurodegeneration.Ocwaningweni lwegundane, imithamo ye-3-10 mg/kg yesisindo somzimba ikhiqize ukunciphisa ukukhathazeka ngaphandle kokubangela ukuthuthumela.[2] Imiphumela ye-Neuroprotective, enikezwe ngokwanda komthamo we-mitochondrial, ibuye yabonwa ezifundweni zezilwane (1-33 μM).

Zimbalwa izifundo zomtholampilo ezihumusha le miphumela kubantu. Izifundo ezimbili ezithembisayo kakhulu zahlola i-apigenin njengesakhi se-chamomile (i-Matricaria recutita) yokukhathazeka kanye ne-migraine. Lapho abahlanganyeli abane-co-diagnoses yokukhathazeka nokucindezeleka banikezwa i-200-1,000 mg ye-chamomile ekhishwe ngosuku ngamaviki angu-8 (okujwayelekile ku-1.2% apigenin), abacwaningi babone ukuthuthukiswa kokukhathazeka okuzibikayo kanye nezikali zokucindezeleka. Esivivinyweni esifanayo esiphambene, abahlanganyeli abane-migraine bathola ukuncipha kobuhlungu, isicanucanu, ukuhlanza, nokuzwela ukukhanya/komsindo imizuzu engu-30 ngemva kokusetshenziswa kwe-chamomile oleogel (0.233 mg/g ye-apigenin).

I-Apigenin ingase futhi ikwazi ukusebenzisa izimpendulo ezinhle ze-physiologic ngokunciphisa i-cortisol, i-hormone yokucindezeleka. Lapho amangqamuzana e-adrenocortical yomuntu (in vitro) evezwe kububanzi bengxube ye-flavonoid engu-12.5–100 μM ehlanganisa i-apigenin njengengxenye, ukukhiqizwa kwe-cortisol kwehle kufika ku-47.3% uma kuqhathaniswa namaseli okulawula.
Emagundaneni, i-apigenin ekhishwe esitshalweni i-Cephalotaxus sinensis yomndeni wakwaPlum Yew ibonise izinto ezithile zokulwa nesifo sikashukela ngokwandisa impendulo ye-physiologic ku-insulin. Le miphumela ayikaphindwa kubantu, nakuba ocwaningweni olunikeze ababambiqhaza isiphuzo sikapelepele omnyama esasiqukethe i-apigenin kanye nenselelo yenselelo yesinkwa sikakolweni, i-blood glucose ne-insulin kwakungehlukile eqenjini lokulawula isiphuzo.
Amahomoni okuzala afana ne-testosterone ne-estrogen angase athonywe i-apigenin. Ezifundweni zangaphambi kweklinikhi, i-apigenin iguqule ama-enzyme receptor kanye nomsebenzi ngendlela ephakamisa ukuthi ingase ibe nomthelela ekusebenzeni kwe-testosterone, ngisho namanani aphansi kakhulu (5-10 μM).
Ku-20 μM, amangqamuzana omdlavuza webele avezwe ku-apigenin amahora angu-72 abonise ukwanda okuvinjiwe ngokulawula ama-estrogen receptors. Ngokufanayo, lapho amangqamuzana e-ovarian evezwa ku-apigenin (i-100 nM amahora angu-48) abacwaningi babona ukuvinjelwa komsebenzi we-aromatase, okucatshangwa ukuthi kuyindlela engenzeka ekuvimbeleni nasekwelapheni umdlavuza webele. Nokho, akukacaci ukuthi le miphumela ingahumusheka kanjani ibe umthamo womlomo ozosetshenziswa abantu.

Izinkinga ze-bioavailability kanye nokuzinza kwe-flavonoid apigenin ngokuzihlukanisa zivame ukuholela ocwaningweni lwabantu olugxile ekusetshenzisweni ngezitshalo, amakhambi, kanye nezingcaphuno zazo. I-Bioavailability kanye nokumuncwa okulandelayo, ngisho nezitshalo nokudla, kungase kuhluke ngomuntu ngamunye kanye nomthombo etholakala kuwo. Ucwaningo oluhlola ukudla kwe-flavonoid (kuhlanganise ne-apigenin, ethathwa njenge-flavone) kanye nendle ehambisana nengozi yesifo, ngakho-ke kungase kube izindlela ezingokoqobo zokuhlola. Ucwaningo olulodwa olukhulu lokubheka, isibonelo, lwathola ukuthi kuzo zonke izigaba ze-flavonoid zokudla, ukuthathwa kwe-apigenin kukodwa kunciphise ubungozi be-hypertension ngo-5% kubahlanganyeli abadle amanani aphezulu, uma kuqhathaniswa nabahlanganyeli abadla okuphansi kakhulu. Nokho, kungenzeka ukuthi kunomunye umehluko ongachaza le nhlangano, njengemali engenayo, engathinta isimo sezempilo kanye nokufinyelela ekunakekelweni, okuholela ekwehleni kwengozi yomfutho wegazi ophakeme. Olunye ucwaningo olungahleliwe alutholanga umthelela phakathi kokusetshenziswa kokudla okucebile kwe-apigenin (u-anyanisi ne-parsley) kuma-biomarker ahlobene nesifo somfutho wegazi ophezulu (isb., ukuhlanganiswa kwamaplatelet kanye nezandulela zale nqubo). I-caveat lapha ukuthi i-plasma apigenin ayikwazanga ukulinganiswa egazini labahlanganyeli, ngakho ukusetshenziswa kwesikhathi eside nokuhlukahluka noma mhlawumbe izindlela ezihlukene, njengezinyathelo zomphumela ezingagxili kuphela ekuhlanganisweni kweplatelet, zingadingeka ukuze uqonde. imiphumela engaba khona.

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